High Beta-Glucuronidase and How it Affects Estrogen and Detoxification

Why Test Beta-Glucuronidase?

Does it feel like something is just off? Do you feel like your hormones are out of balance, digestion is not 100% or just have general health issues?

Could it be high beta-glucuronidase levels that are the cause of your high estrogen levels, or causing problems with liver detoxification?

One of the ways the body gets rid of toxins is through a process called conjugation which happens during phase 2 of liver detoxification.

During conjugation, toxins are packaged into water-soluble compounds in a process known as glucuronidation. Through this process toxins and hormones are meant to pass through the liver, to the bile, then to the gut where they are excreted.

However, high levels of an enzyme called beta-glucuronidase can inhibit this process.

This enzyme separates toxins from their conjugate bond and allows them to be reabsorbed. Toxins and hormones like estrogen get reabsorbed into the body and make you feel tired, and out of balance without realizing why.

If you are worried that you don’t feel quite yourself, then you always want to get that checked out.  A good place to start is checking your digestive health markers.

The reality is that gut health is of the utmost importance to every area of your well being, and beta-glucuronidase is one marker that we test at Planet Naturopath because of its effect on your ability to detoxify, and it can cause high estrogen levels which is a common problem for many people.

Beta-glucuronidase can be tested in a stool sample with the G.I Map test

Beta-Glucuronidase and Detoxification

We hear so much about the need for taking probiotics and how gut bacteria contribute to better gut health, but we hear very little about beta-glucuronidase.

Beta-glucuronidase is important for proper digestion and in particular phase 2 of liver detoxification. If your levels are out of balance it can affect your ability to detoxify estrogen and other hormones, as well as environmental toxins.

What Is Beta-Glucuronidase and How Does It Impact Your Health?

You may not understand the science of the gut and how the different bacteria and enzymes can influence our health. However, you should be aware of beta-glucuronidase, which is a very important enzyme within the gut and is involved in phase 2 of liver detoxification.

This is an enzyme that plays a pivotal role in digestion, particularly in breaking down certain things such as complex carbohydrates, detoxification of estrogen, thyroid hormone and other environmental toxins.

However, If the levels of beta-glucuronidase enzyme get too high, then this creates a very undesirable situation. You will start to reabsorb hormones like estrogen and toxins that should be eliminated.

This is one of the main causes behind high estrogen. Many people take DIM supplements to improve estrogen detoxification but if your phase 2 of liver detoxification is not working well then you can reabsorb them back into your body, no matter how much DIM or broccoli you eat.

If your levels get too high of beta-glucuronidase then this can interrupt the body’s natural detoxification process.

The liver can’t work to detoxify your body if levels of beta-glucuronidase are too high. When your body comes into contact with toxins or environmental chemicals, they are re-absorbed back into the body rather than being eliminated through the gut.

These can make you sick over time and can lead to a whole host of health conditions in the future. So when the liver can’t properly work through the detoxification process, you are hurting your health now and in the long term as well.

What Puts You At Risk and How Can It Be Detected?

You might not realize that you have high levels of beta-glucuronidase. These are the things that will increase your levels.

  • If you have a poor diet then this can put you at risk of this enzyme being produced at high levels.
  • If you are an individual that consumes a lot of meat, processed foods, sugar, or alcohol then you are at risk of elevated levels of beta-glucuronidase.
  • Therefore, a healthy foundation that focuses on proper and balanced nutrition is of the utmost importance moving forward.

    High levels of beta-glucuronidase can be a sign of other imbalances in your digestive tract like candida and bacterial overgrowth, this is also known as dysbiosis.

    While supplements such as Calcium D-Glucarate can help lower beta-glucuronidase in the short term it is always best to address the underlying cause of why you have high levels of beta-glucuronidase.

    Understanding the role that beta-glucuronidase has on your digestive, hormonal and other areas of health is important, and the best way to know is to “test and not guess”. This enzyme tends to be in the colon and so there are a couple of simple but effective ways to test for it.

    At Planet Naturopath we use the G.I Map test to measure your beta-glucuronidase levels. The other advantage of using this test is that you can also assess bacterial overgrowth and candida which can be the cause of high beta-glucuronidase levels.

    What Other Problems Can Elevate Beta-Gluronidase Levels Cause?

    The reality is that if the beta-glucuronidase levels remain elevated over time, this can lead to significant health issues in the future.

    You put yourself at risk of certain types of cancer if this remains in your system. This can be particularly true for hormonally based types of cancer since the elevated levels of beta-glucuronidase can interfere with hormone balance. This can put you at greater risk for breast cancer and other hormone-related cancers.

    It is possible that elevated levels of beta-glucuronidase can lead to an interruption to estrogen regulation within the body. Not only can this lead to hormone-based types of cancers, but also an interruption in detoxification in this capacity.

    It may be that the natural estrogen detoxification process doesn’t work properly, thus leading to other issues associated with high estrogens like weight gain, mood changes, and PMS.

    Foods and Supplements That Can Help

    Calcium D-Glucarate is an excellent supplement that can help with elevated levels of beta-glucuronidase. It is great to help naturally detoxify the body and can, therefore, lower your elevated levels in the meantime.

    I recommend starting at 1,000mg a day but if your beta-glucuronidase levels are a lot higher you may need more. Make sure to choose a good brand like Thorne Research.

    Calcium D-Glucarate

    It can lower high beta-glucuronidase levels.


    A stool test will also reveal if dysbiosis is a contributing factor, the Viome Stool test is another option if you want to do a test that is cheaper than the GI Map but still assesses dysbiosis. If this is the case you may also find that taking a probiotic helps with natural gut health.

    Though this is an indirect way of dealing with elevated levels of beta-glucuronidase. It most certainly can help with the issue and restoring gut health.

     I recommend the Seed Probiotic to help balance gut bacteria.

    Jarrow Formulas Ideal Bowel Support 299v

    It improves intestinal health and function.


    The herb Milk Thistle, otherwise known as Silymarin can also help to lower beta-glucuronidase and help liver detoxification in general.

    NOW Silymarin 

    It supports liver function and reduces  beta-glucuronidase levels.


    You may also find that eating a healthier and balanced diet can help with the problem. Try limiting processed meats, alcohol, and avoid sugar and processed foods that can lead to elevated beta-glucuronidase.

    Focus on plenty of fruits and vegetables, good fats, and lean proteins separate from grass-fed animals.

    Taking a proactive approach to managing your beta-glucuronidase levels can help your liver to function properly, balance out hormones, and can lead to natural detoxification. Be sure that you understand your beta-glucuronidase levels and the implications of this enzyme in elevated amounts.

    About the Author Michael

    Michael is head consultant at Planet Naturopath - Functional Medicine and Nutrition Solutions. He is a registered naturopath with the Australian Natural Therapists Association (ANTA) and works with clients from all over the world via video or phone consultations. He is a degree qualified naturopath from the Endeavour College of Natural Medicine in Australia with 18 years of experience. He uses advanced testing methods, nutritional medicine, herbal medicine, and lifestyle advice to help you stay healthy. He is a Kalish Method-trained practitioner that keeps updating his education with Chris Kresser. Michael completed Dr. Terry Wahls practitioner training program, a 12-month program with ongoing training that helps understand the underlying cause and treatment of MS and autoimmune conditions. He keeps up to date with the latest research into health and natural medicine through the Metabolic Fitness Pro course with Dr. Bryan Walsh.

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    Leave a Comment:

    Kristin Jaeger says November 13, 2017

    Thank you so much for the article! I have high beta glucoronidase levels and I’ve been researching how to lower them. I don’t drink alcohol, I’ve been vegetarian for 20+ years and never touch pressed foods. I do eat sugar occasionally, but I am surprised I tested so high for this. Thanks for all the info!

    Lyryn says August 9, 2018

    Calcium d glucarate is incredible for lowering high betaglucaronidase!!!! I have done the pre and post data!!!! Personally. A true life saver!

      Michael says August 11, 2018

      I am glad you have seen great results.

      Yes Calcium D Glucarate can be great to help lower beta glucuronidase but you also want to address any bacterial overgrowth that can be the underlying cause of the high levels

        Elena Okhonko says October 27, 2019

        But normal doctors do not seem to know how to treat bacterial overgrowth except prescribing pro-pre biotics. Any other options?

          Michael says October 27, 2019

          If you have tested positive to high levels of bacteria the treatment can depend on the number of bacteria and what type of bacteria or co-infections like H.pylori or parasites are present – this is why I recommend the G.I Map test to help identify exactly what is going on.
          I find that doctors would normally go for antibiotics rather than probiotics and prebiotics (so if your doctor recommends probiotics that is a good start), herbal anti-microbials usually prescribed with an agent to break down biofilms is a very effective option.

    Daniel says January 19, 2019

    Interesting article!
    I have a question:
    Why is red meat bad for the beta glucoronidase levels?
    Or do you only mean processed red meat like knackwurst, dried beef etc.?

      Michael says January 28, 2019

      It is not red meat specifically but high amounts of red meat – especially if they are processed AND high amounts of other processed foods

    Rosa Fasching says March 18, 2019

    As you might know, beta-glucuronidase is a bacterial enzyme by the E. coli gut bacteria. Why do you recommend Lactobac.? You must recommend the commensal E. coli in order to substitute the pathological E. coli, that’s all.

      Michael says May 6, 2019

      Lactobac is not recommended in the article

    Maha says March 26, 2019

    What if the beta glucoronidase was on the law side, does it still obstruct detoxification ? Thanks

      Michael says May 6, 2019

      No, it is a problem if it is very high

        Stacey Bartley-Smith says September 6, 2020

        Hi there, could you please give an indication of a VERY high level? Mine was just above the top end of the parameters.

          Michael says September 29, 2020

          Very high would be 4,000 plus – mildly elevated I would focus on dysbiosis

    Courtney says August 10, 2019

    My beta glucuronidase is very low. What does that mean?

      Michael says August 12, 2019

      Low levels are not usually a problem, it is only high levels that will affect detoxification

    Mary says August 23, 2019

    My levels are 28,231. I think very high. I was told to use a probiotic. I seem to crave sweets. Would it be necessary for the Calcium D-Glucarate at this time. And is this a situation of . . . do I have SIBO.

      Michael says August 25, 2019

      Hi Mary – you can’t identify SIBO from just assessing b-glucuronidase. You do have high levels but I don’t make specific recommendations without assessing all of the lab results and taking a personal history, and this can only be done during a consultation

    Maya says September 30, 2019

    How much is high? my reading is within the range but the high end . it is 3500. is it normal?

      Michael says October 3, 2019

      Your levels are on the higher side, for some people this is ok but if you have symptoms of estrogen dominance you may want to address gut health or consider supplementing with calcium d glucarate

    Tyson Macinnis says November 4, 2019

    Hi there…can supplementing with magnesium calcium and zinc cause beta glucuronidase levels to rise?

      Michael says November 4, 2019

      Hello Tyson

      Mineral supplements should not cause a rise, it is usually bacteria overgrowth or detox issues

    Leeann says February 6, 2020

    I was prescribed Indole-3-carbinol to reduce my levels, along with herbal antimicrobials and digestive support to help with malabsorption & SIBO. How does Indole-3-carbinol compare to Calcium D Glucarate? I cannot stomach the smell of Indole-3-carbinol, and my doctor recommended DIM instead.

      Michael says February 6, 2020

      Hi Leeann

      The Indole-3-carbinol works in a similar way to DIM and it helps to improve phase 1 of liver detoxification, especially detoxification of estrogen but it does not lower b-glucuronidase. The Calcium d glucarate is specific for lowering b-glucuronidase.
      Did you do the DUTCH hormone test? This can help identify if you need DIM and well your phase 1 detoxification is working https://www.planetnaturopath.com/dutch-test/

    Joy Dryer says February 8, 2020

    Are there any essential oils that would be good for High Beta Glucoronidase?….using them topically works well for me.

      Michael says February 14, 2020

      Essential oils would not be my first go-to treatment

    Becky Pratt says August 11, 2020

    Would you supplement for a beta-glucaronidase level of 2674?

      Michael says August 11, 2020

      Hi Becky – that level is not too high and while calcium d glucarate would help to improve this reading I would be assessing your overall gut health to find out why the level is so high in the first place

        Becky Pratt says August 12, 2020

        So it’s the gut that causes high v-glucaronidase as opposed to the liver?

    Celine says September 14, 2020

    I did go map test and have klebsiella and high b.glucodinase. Don’t know what to do. I 57 yr live in Israel and wonder if you can help me

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