Cyrex Tests: 9 of the Most Popular Options


Cyrex testing is ideal for identifying digestive problems, food intolerances, autoimmune triggers and identifying/ preventing chronic health issues.

There are a number of different Cyrex tests called arrays,  you can start with one test or do a combination to help identify underlying health issues. If you get the results from a Cyrex test and then you decide that you want to add more tests this can be done with the original blood sample within the first 2 weeks.

Here is a list of the common Cyrex tests, these tests are available worldwide but the lab is located in the U.S.A and the prices are in USD.

*If you are outside of the U.S extra shipping charges will apply, contact to get the price in your country.

Note: Testing is not available in the state of New York

Cyrex Test Array 2 Intestinal Permeability Screen- $295

Cyrex Tests: 9 of the Most Popular Options 1

Intestinal permeability, commonly known as the leaky gut is a condition where the intestinal wall lets undigested food particles or other substances pass into the bloodstream.

There are a few known antigens present with intestinal permeability and those include Actomyosin, Occludin, Zonulin, and Lipopolysaccharides (LPS). These markers can help to identify the underlying cause of leaky gut which can help with your treatment plan.

  • LPS are large molecules found in gram-negative bacteria. They are endotoxins and trigger a strong immune and inflammatory response if absorbed. 
  • Occludin is part of the main component of proteins holding together tight junctions (that connect individual intestinal wall cells to each other). The detection of Occludin antibodies suggests that tight junctions are breaking down.
  • Zonulin is the protein that directly regulates the permeability of the intestine. Antibodies to zonulin indicate compromised tight junction regulation. This can be caused by food intolerances or pathogens.
  • Actomyosin forms a protein complex that regulates the intestinal barrier function by maintaining tight junctions. This can be caused by bacteria infiltration of the intestinal barrier or due to an autoimmune response.

Cyrex Array 3 - Wheat/ Gluten Reactivity and Autoimmunity - $369


Current testing for Gluten-Reactivity and Celiac Disease includes only serum IgG and IgA against gliadin and tissue transglutaminase

The Cyrex Array 3X is designed to distinguish between celiac and non-celiac gluten sensitivity, the Array 3 tests for three antigen triggers: gluten proteins, opioid peptides, and tissue binding isolates.

In total the Array 3X tests for 32 different markers instead of the two markers reported on the standard gluten test done at your doctor's office.

To do this test you need to be eating gluten products for around 4 weeks before the test, so if you have already eliminated gluten from your diet you either need to reintroduce gluten before testing, or continue to avoid it but don’t do the test.

Alternative to the Cyrex Array 3 is the Vibrant Wellness Wheat Zoomer which is $300

This test is ideal for people with chronic health issues but they are unsure if they are reacting to gluten or not, sometimes people can have zero digestive issues but still be having an immune response to gluten that can cause other health issues.


Cyrex Array 4 - Gluten Cross-Reactivity Foods and Food Sensitivity - $350


In cross-reactivity, the body may mistake another food for gluten and react in the same way you would react to gluten. Cyrex Array 4 tests for 24 different foods that may be causing cross-reactivity or are newly introduced to the diet or over-consumed favorites.

It can be frustrating to eliminate gluten from the diet and see some improvement, but you suspect that there could be other foods that are triggering similar reactions to gluten. Research shows that this can be due to gluten cross-reactivity

One of the most frustrating scenarios for both the practitioner and the patient is when a gluten-free diet fails to have any effect on a person who seems so clearly gluten sensitive. Newer research shows this may be due to cross-reactivity.

Cyrex Test Array 5 - Multiple Autoimmune Reactivity Screen - $695


Many studies show that autoimmune antibodies can be elevated in the blood many years before symptoms occur. Cyrex Labs have now developed their Array 5, a comprehensive autoimmune screen that helps in the early detection of autoimmunity.

If detected early, natural and/or medical interventions can begin in order to minimize long-term illness and promote a better quality of life.

24 different autoimmune antibodies against your body’s organs are tested in this panel. Due to the fact that more than 40% of those with auto-antibodies to one organ have auto-antibodies to other organs and tissues of the body, this is an ideal test for anyone who has an autoimmune condition already or anyone with a family history of autoimmune problems.

Elevated auto antibodies, known as Predictive Antibodies, are measurable up to ten years before the clinical onset of the disease. Early identification of autoimmunity can help to possibly stop or reverse disease progression. Array 5 looks at multiple tissues commonly targeted by auto-antibodies, including Cardiovascular, Endocrine, Joint, Gastrointestinal, Neurological, and more.

Cyrex Test Array 10 - Multiple Food Reactivity Screen - $595


The Cyrex Array 10 assesses 180 different foods using cooked and raw foods, including meats, vegetables, fruits, spices, grains, nuts, beverages, food additives, and gums that are found in processed foods.

Food intolerances are known to cause multiple health issues connected to the immune system including autoimmune and neurological diseases.

Clinical Use:

  • Evaluate immune reactions to foods, raw and/or modified, food enzymes, lectins, and artificial food additives, including meat glue, colorings, and gums.
  • Early detection of dietary-related triggers of autoimmune reactivity.
  • Monitor the effectiveness of customized dietary protocols

Recommended for Patients Who:

  • Seek a life-long health and wellness strategy.
  • Present with unexplained symptoms whether gastrointestinal, neurological, dermatological, or behavioral in nature.
  • Are suspected of having increased intestinal permeability, which is the gateway for environmentally-induced autoimmune disorders.
  • Alternative to the Cyrex Array 10 would be the Vibrant Wellness Food Sensitivity testing, they have two comprehensive options and one includes food additives

Cyrex Test Array 12 - Pathogen Associated Immune Reactivity - $499 


The Cyrex Array 12 tests for 29 different pathogens including candida, molds, bacteria, parasites, viruses, and Lyme disease - all of these can be triggers for autoimmune, digestion, and other chronic health problems.

Clinical Use:

  • Detect immune reaction to key pathogens that may lead to multiple autoimmune reactivities.
  • Determine the role of pathogens in cases of ‘unexplained’ autoimmune reactivities.
  • Monitor the effectiveness of clinical protocols for addressing pathogens associated with multiple autoimmunities.

Recommended for Patients Who:

  • Present with chronic conditions such as gastrointestinal distress, fatigue, body aches or unexplained and general inflammation, including neuroinflammation.
  • May have been exposed to bacteria, viruses, parasites, molds, and spirochetes associated with multiple autoimmunities.
  • Have not fully responded to clinical interventions, such as detoxification and dietary modifications.

Antigens Tested (IgG)

  • Porphyromonas gingivalis
  • Streptococcus mutans
  • Helicobacter pylori
  • Campylobacter jejuni
  • Yersinia enterocolitica
  • Clostridium difficile
  • Candida albicans
  • Rotavirus
  • Entamoeba histolytica
  • Giardia lamblia
  • Cryptosporidium parvum
  • Blastocystis hominis
  • Human HSP-60 + Chlamydia HSP-60
  • Chlamydias
  • Streptozymes
  • Streptococcal M Protein
  • Mycoplasmas
  • Acinetobacter
  • Klebsiella
  • Mycobacterium avium
  • Aspergillus
  • Penicillium
  • Stachybotrys chartarum
  • Citrullinated EBV
  • CYP450, mimic Hepatitis C Peptide
  • Cytomegalovirus
  • Human Herpesvirus-6
  • Borrelia burgdorferi
  • Babesia +Ehrlichia +Bartonella

Cyrex Test Array 20 - Blood-Brain Barrier Permeability - $325


The blood-brain barrier (BBB) is a physical barrier formed by the arrangement of endothelial cells and tight junctions that line the capillaries which supply blood to the brain. It is a highly selective barrier that restricts the movement of molecules from the blood across to the brain. 

The BBB naturally permits the passage of essential metabolites, small hydrophobic (lipid-soluble) molecules like oxygen, carbon dioxide, hormones, etc. Acting as a filter, the BBB prevents the entry of infectious agents, toxins, and other environmental triggers into the nervous system.

Clinical Use:

  • Early investigation in the management of contact sports-related Traumatic Brain Injury (TBI)
  • Evaluation of breach of the Blood-Brain Barrier by stress, trauma, or environmental triggers, even in the absence of apparent concussion or brain injury
  • Assist in the assessment of the increased risk of neurodegenerative disorders including, but not limited to, Multiple Sclerosis, Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease), Senile Dementia, Alzheimer's Disease, Parkinson's Disease, Epilepsy, and Stroke

Recommended for Patients Who:

  • Play contact sports during which repeated head trauma occurs
  • Engage in an activity that involves force or shock to the body and/or head
  • Have intestinal permeability with abnormal elevation in LPS and/or Occludin/Zonulin antibodies
  • Exhibit changes in cognitive function

What's Being Tested:

  • Blood Brain Barrier Protein IgA + IgG
  • Blood Brain Barrier Protein IgM

Cyrex Test Array 22 - Irritable Bowel/ SIBO Screen - $359


Clinical Use:

  • Identify the overgrowth of large intestinal bacteria in the small intestine and the release of bacterial cytotoxins
  • Evaluate a breach of the intestinal barrier by bacterial cytotoxins and their entry into circulation
  • Assist in setting guidelines for the treatment of irritable bowels/SIBO and reduce the risk of igniting the autoimmune process

Recommended for Patients Who:

  • Have irritable bowels
  • Exhibit symptoms of malabsorption, including weight loss, anemia, or fatty stools
  • Have associated conditions such as fatigue, reflux, skin disorders, obesity, or food intolerances

Antigens Tested

  • Cytoskeletal Proteins IgG
  • Cytoskeletal Proteins IgA
  • Cytoskeletal Proteins IgM
  • Bacterial Cytotoxins IgG
  • Bacterial Cytotoxins IgA
  • Bacterial Cytotoxins IgM

Cyrex Alzheimer’s Linx - Alzheimer’s Associated Immune Reactivity - $595


Clinical Use:

  • To identify patients at greater risk for developing Alzheimer's disease or other neurological disorder.
  • To identify reactivity to triggers of Alzheimer's disease or other neurological disorder.
  • To identify the early stage of neurodegenerative processes.
  • To monitor the effectiveness of lifestyle modifications for Alzheimer's disease.

Recommended for Patients Who:

  • Are interested in preventing the development of Alzheimer's disease or other neurological disorders.
  • Are exhibiting early signs of Alzheimer's disease or other neurological disorders.
  • Have been diagnosed with Alzheimer's disease.
  • Have a history of gastrointestinal disorders and/or diabetes.
  • Played high-impact sports.
  • Are immunoreactive against specific pathogens, chemicals, and foods.

Antigens Tested

  • Brain Proteins
  • Tau Protein IgG
  • Amyloid-Beta Peptide IgG
  • Rabaptin-5 + Presenilin IgG
  • Alpha-Synuclein IgG
  • Growth Factors
  • Beta Nerve Growth Factor IgG
  • Brain Derived Neurotrophic Factor IgG
  • Neurotrophins IgG
  • Somatotropin IgG
  • Enteric Nerve, Enzymes, and Neurological Peptides
  • Enteric Nerve + Vasoactive Intestinal Peptide IgG
  • Transglutaminases IgG
  • Pathogens
  • Oral Pathogens IgG
  • Enterococcus faecalis IgG
  • Escherichia coli CDT + Salmonella CDT IgG
  • Campylobacter jejuni CDT IgG
  • Herpes Type-1 IgG
  • Chemicals
  • Aluminums IgG
  • Dinitrophenyl IgG
  • Ethyl + Methyl Mercury IgG
  • Phthalates IgG
  • Foods Cross-Reactive to Amyloid-Beta
  • Egg Yolk, raw + cooked IgG
  • Lentil Lectin + Pea Lectin IgG
  • Tuna, canned IgG
  • Hazelnut Vicilin + Cashew Vicilin IgG
  • Scallops + Squid IgG
  • Caseins IgG
  • Alpha-Gliadin + Gliadin Toxic Peptide IgG
  • Non-Gluten Wheat Proteins IgG
  • Blood-Brain Barrier and Neurofilaments
  • Blood-Brain Barrier Protein + Claudin-5 IgG
  • Aquaporins IgG
  • Neurofilaments Proteins IgG

Cyrex Tests - The Next Steps

With so many different options with the Cyrex tests it can be difficult to know what the best options are for you - the best option is to schedule a 30 minute consultation so I can assess your health, review previous tests and make recommendations specifically for you.

Also Cyrex offers discounts when you order certain combinations of tests, if you are interested in ordering 2 or more tests let us know and we can see if there is a cheaper price.

Also it is possible to order 1-2 of the Cyrex test arrays and once the results are back we can order more tests if necessary from the original blood draw, this is especially important if you are shipping tests from outside of the U.S

If you know which of the Cyrex test arrays you would like to order contact and we can get the process started.

Was this article helpful?

Affiliate Disclosure

This website contains Amazon affiliate links, which means we may receive a percentage of any product or service you purchase using the links in the articles or advertisements. You will pay the same price (or get a discount) for all products and services, and your purchase helps support Planet Naturopath’s ongoing research and work. Thanks for your support!

Planet Naturopath Editorial Policy