Cyrex Array 3X Test (identify celiac or gluten sensitivity)

The Cyrex Array 3X Test is one of the most advanced test available which can help to identify if you are celiac or sensitive to gluten.

More and more people are avoiding gluten because of its link with digestive problems, autoimmune conditions and other health issues.

But is it really necessary to avoid gluten?

Gluten is everywhere. Foods containing gluten are wheat, oats, barley, and rye. So it would make life easier if you did not have to be 100% gluten free!

Being 100% gluten free is absolutely necessary if you are celiac , and for some people with autoimmune conditions or non-celiac gluten sensitivity they will feel a lot better if they are also gluten free.

But for the rest of us is it really necessary to be gluten free?

Well the Cyrex array 3 blood test can help you to understand if you need to cut out gluten 100%, or just reduce your gluten intake.

Why Avoiding gluten Is A Good Idea

Research shows that gluten can be a contributing factor in many different health conditions.

Some symptoms and disorders caused by Gluten intolerance are:

  • Depression
  • Headaches
  • Chronic anemia
  • Bipolar Disorder
  • Schizophrenia
  • Eczema
  • Autoimmune
  • Autism
  • Fibromyalgia
  • Dementia
  • Alzheimer's
  • Chronic Fatigue 

Celiac Disease Or Gluten Sensitivity

If you think you are reacting to gluten how do you know if it is celiac disease of gluten sensitivity?

Or if you get bloated and gassy after eating bread it may not be the gluten at all, you maybe reacting because wheat is a high FODMAP food.

Gluten can cause brain fog and other cognitive symptoms, but if you get neurological symptoms every time you eat bread it may also be the preservatives in flour that are causing the problems.

Doing a month long elimination of gluten can help to identify if you have an issue with gluten containing foods.

What happens if you feel good for cutting out gluten?

Does that mean that you have to avoid gluten forever?

If you want to identify why you are having issues, or if you would like to know if you need to cut out gluten 100%, or simply reduce gluten containing foods (or avoid flour products with preservatives) then the Cyrex Array 3X test is the best option.

What is gluten sensitivity?

Gluten sensitivity is when your body cannot tolerate protein found in grains like wheat, barley, and rye. It is not life-threatening, but it can be very uncomfortable and can affect daily life. 

The symptoms of gluten intolerance are:

  • Abdominal pain.
  • Anemia.
  • Anxiety.
  • Bloating or gas.
  • Brain fog, or trouble concentrating.
  • Depression.
  • Diarrhea or constipation.
  • Fatigue.

The symptoms above could be caused by gluten or they cold be caused by another food sensitivity, gut infections, stress, low digestive enzymes or a number of other reasons.

What is celiac disease?

Celiac disease is a well-recognized medical condition in which gliadins (gluten proteins found in wheat, barley and rye) cause an autoimmune reaction which destroys the lining of the small intestine. 

This can lead to a wide range of digestive symptoms and malabsorption of nutrients.

However, it is possible that some celiac patients have no digestive symptoms, even though their body is still being damaged, this is known as silent celiac disease.

Some people may have mild digestive symptoms but experience neurological and psychiatric symptoms, or skin issues instead of the classic digestive system problems. 

Simply put, the Cyrex Array 3 will rule out if you have a wheat allergy or gluten intolerance or Celiac Disease.

Array 3X Test is recommended for people with the following symptoms:

  • Have non-responsive GI symptoms
  • Chronic digestive system issues
  • Present multiple-symptom complaints (including autoimmune conditions,  Chronic Fatigue Syndrome and Fibromyalgia)
  • Suffer from depression or neurological conditions
  • Have gut dysbiosis, which is not responding to treatment
  • Are suspected of having intestinal mucosal damage
  • Complaints of food allergies and intolerance
  • Complain of chemical hypersensitivity
  • May suffer from blood-brain barrier permeability, depression, or neurological conditions.

So let's look at the best test for testing gluten reactivity.


Sample of the Cyrex array 3X test result

Why Do The Cyrex Array 3X Test

Have you been tested for celiac disease only to be told that everything is fine?

The standard celiac test measures gliadin antibodies and transglutaminase-2 IgG and IgA , if you test positive to transglutaminase then you have celiac disease.

However, if you test negative on the standard celiac test that does not 100% rule out celiac disease as there is transglutaminase markers that they do not test for.

This is where the Cyrex array 3 test from Cyrex labs comes in, this can help to know exactly why you are reacting to gluten and if you need to minimize or avoid 100%

Cyrex Laboratories array 3 is a blood test which aids in an accurate analysis of gluten and wheat to see if you are reacting, even if the standard test shows you are fine.  

The Cyrex Array 3 is a blood test that measures antibody production against 8 wheat proteins and peptides and 3 essential enzymes. It is the only test available with comprehensive panels for establishing which component of the wheat protein challenges your immune system. 

If your immune system is challenged this can lead to problems such as allergies, asthma, and autoimmune disease. 

If you have an autoimmune disease, your immune system will attack healthy cells in your body by mistake. Other immune system problems will also happen when your immune system does not work correctly. 

The Cyrex Array 3 also includes various tissue transglutaminases, which indicate tissue damage to various tissues in the body including neural tissue.

A positive reaction to Transglutaminase 2, 3, or 6 IgA would indicate celiac disease.

Cyrex array 3X test guide

The full range of antigens tested includes:

IgA AND IgG tested separately for each antigen

  • Wheat
  • Wheat Germ Agglutinin
  • Non-Gluten Proteins - A
  • Non-Gluten Proteins - B
  • Gliadin Toxic Peptides
  • Native + Deamidated Alpha-Gliadin-33-mer
  • Alpha-Gliadin-17-mer
  • Gamma-Gliadin-15-mer

  • Omega-Gliadin-17-mer
  • Glutenin-21-mer
  • Gluteomorphin + Prodynorphin
  • Gliadin-Transglutaminase Complex
  • Microbial Transglutaminase
  • Transglutaminase-2
  • Transglutaminase-3
  • Transglutaminase-6

How To Interpret The Cyrex Array 3x Test

It is important to work with your practitioner when analyzing the Cyrex tests but to give you an overview of what the results mean these images below will help you with the array 3 interpretation.

Cyrex array 3X test interpretation

The above markers are mainly used to assess wheat or gluten sensitivity

Cyrex array 3 test interpretation

The transglutaminase markers are indicative of celiac disease

Cyrex Array 3X Test Frequently Asked Questions

Q/ Who should not do the Cyrex array 3X test?

A/ If you are already following a gluten free diet or you have been diagnosed with celiac disease already then the Cyrex test is not the best option for you. You need to be eating gluten in the 30 days before testing.

Q/ How To Order The Cyrex Array 3X Test

A/ You can order the test directly from Planet Naturopath, the test needs a doctor's referral which we will provide and I recommend scheduling a consultation once the results are ready.

Q/ How do you prepare For The Cyrex Array 3 Test?

A/ It is important that you are eating gluten containing foods on a regular basis in the month leading up to the test, you need to do this to challenge your immune system and avoid a false positive.

Q/ Can international clients do the Cyrex lab tests?

A/ Yes but there will be extra shipping charges and you will be responsible for organizing the blood draw. If the samples are sent back to the lab via FedEx or DHL they will arrive within the 10 day period to ensure validity of the samples.

For clients outside the U.S they are best to do the Vibrant Wellness Wheat Zoomer

Q/ Are there alternatives to the Cyrex Array 3 Test?

A/ Yes the Vibrant Wellness Wheat Zoomer is another option, it is similar to the Cyrex Test in many ways but it does have the advantage of not requiring a blood draw. The Wheat Zoomer is a dried blood spot test which makes this test a lot easier to ship internationally, plus the Wheat Zoomer is only $300

Find out more about the Vibrant Wellness Wheat Zoomer

Q/ If I order several Cyrex tests together can I get a discount?

A/ If you order the Cyrex array 2, 3, and 4 tests together then Cyrex will provide these at a discounted rate.

*Cyrex array 2 tests for intestinal permeability (leaky gut) and Cyrex array 4 assesses for gluten cross reactive foods.

Cyrex laboratory adheres to the highest standards of lab testing worldwide and specializes in tests to measure immune reactivity, intestinal permeability, blood brain barrier function, autoimmune reactivity, and food sensitivities.

To find out more about the other Cyrex tests that are available read this article.

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